Clinicopathologic significance of TROP2 and phospho?TROP2 in gastric cancer

Trophoblast cell?surface antigen 2 (TROP2) is a transmembrane glycoprotein expressed in epithelial cells. Increased TROP2 expression has been reported to be associated with malignant progression most carcinomas; however, tumor?suppressive function certain types of cancer. Since the controversial, present study subsequently aimed clarify clinicopathologic significance and pTROP2 human gastric cancer (GC). The cases 704 patients GC who underwent gastrectomy were retrospectively analyzed. levels each tumor evaluated by immunohistochemistry. association between features their tumors was identified 330 (46.9%) 306 (43.5%) GC, respectively. histological intestinal type, high invasion depth (T3/T4), lymph node metastasis, lymphatic venous invasion. By contrast, increased low (T1/2), no metastasis poorer overall survival (OS) (P<0.01; log rank test), whereas significantly improved OS test). In conclusion, TROP2, but not pTROP2, may metastatic ability resulting poor prognosis GC.